Magnesium → 3-[3-(1-Amino-1-methyl-ethyl)-phenyl]-2-methyl-propionic acid methyl ester

HRID 1785455Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1785455
[CH3:1][O:2][C:3](=[O:17])[C:4]([CH3:16])=[CH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([NH2:15])([CH3:14])[CH3:13])[CH:7]=1.[Mg]>CO>[CH3:1][O:2][C:3](=[O:17])[CH:4]([CH3:16])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([NH2:15])([CH3:13])[CH3:14])[CH:7]=1

Komponenten

4

Edukt 2

HCID 5462224MagnesiumHCID 690673703-[3-(1-Amino-1-methyl-ethyl)-phenyl]-2-methylacrylic acid methyl ester

Produkt 1

HCID 575931893-[3-(1-Amino-1-methyl-ethyl)-phenyl]-2-methyl-propionic acid methyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

The mixture of 3-[3-(1-amino-1-methyl-ethyl)-phenyl]-2-methylacrylic acid methyl ester (2.0 g, 8.6 mmol), magnesium (0.63 g, 25.8 mmol) in methanol was heated to reflux for 3 h until the starting material was consumed. The mixture was brought to room temperature, filtered and the filtrate was concentrated. The residue obtained was washed with saturated NH4Cl, brine, dried over magnesium sulfate and concentrated.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureto reflux for 3 h until the starting material
  3. customwas consumed
  4. customwas brought to room temperature
  5. filtrationfiltered
  6. concentrationthe filtrate was concentrated
  7. customThe residue obtained
  8. washwas washed with saturated NH4Cl, brine
  9. dry with materialdried over magnesium sulfate
  10. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-69ee3bd99eda4cc58d6d1e27af82a7af
Quelldatensatz
uspto-grants-2009_03
Patentnummer
US07504403B2

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