p-(Difluoromethoxy)benzaldehyde → 2-(Trifluoromethyl)-4'-(difluoromethoxy)benzhydrol

HRID 1785719Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1785719
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[Mg]Br.[F:13][CH:14]([F:24])[O:15][C:16]1[CH:23]=[CH:22][C:19]([CH:20]=[O:21])=[CH:18][CH:17]=1.FC(F)(F)C1C=C(Cl)C=CC=1C(O)C1C=CC=CC=1>>[F:1][C:2]([F:12])([F:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:20]([OH:21])[C:19]1[CH:22]=[CH:23][C:16]([O:15][CH:14]([F:13])[F:24])=[CH:17][CH:18]=1

Komponenten

4

Edukt 3

HCID 2736986p-(Difluoromethoxy)benzaldehydeHCID 68907806(4-Chloro-2-(trifluoromethyl)phenyl)(phenyl)methanolHCID 178506141HCID 178506141, Verbindung

Produkt 1

HCID 689024852-(Trifluoromethyl)-4'-(difluoromethoxy)benzhydrolAusbeute 64 %

Versuchsvorschrift

This material was prepared from 2-(trifluoromethyl)phenylmagnesium bromide (16 mmol) and 4-(difluoromethoxy)benzaldehyde (2.09 mL, 15 mmol) using the procedure described for compound (96). The product was obtained as an amber gum (3.05 g, 64%).

Quellen und Nachweise

ORD-Eintrag
ord-6218bdcc60e6473797af67e748ba2783
Quelldatensatz
uspto-grants-2009_03
Patentnummer
US07504522B2

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