Trimethylsilyldiazomethane → 2-Tert-butoxycarbonylamino-4-hydroxy-butyric acid methyl ester

HRID 1786046Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1786046
[C:1]([O:5][C:6]([NH:8][CH:9]([CH2:13][CH2:14][OH:15])[C:10]([OH:12])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:16][Si](C=[N+]=[N-])(C)C>CO>[CH3:16][O:11][C:10](=[O:12])[CH:9]([NH:8][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])[CH2:13][CH2:14][OH:15]

Komponenten

4

Edukt 2

HCID 167693TrimethylsilyldiazomethaneHCID 41186272-(((Tert-butoxy)carbonyl)amino)-4-hydroxybutanoic acid

Produkt 1

HCID 68578092-Tert-butoxycarbonylamino-4-hydroxy-butyric acid methyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

2-tert-Butoxycarbonylamino-4-hydroxy-butyric acid (0.79 g, 3.6 mmol) was dissolved in 15 ml methanol at room temperature and (trimethylsilyl)diazomethane (2M solution in hexane) was added till solution become yellow. The mixture was concentrated down to afford crude 2-tert-butoxycarbonylamino-4-hydroxy-butyric acid methyl ester.

Aufarbeitung

  1. concentrationThe mixture was concentrated down

Quellen und Nachweise

ORD-Eintrag
ord-5ce92dc187844cc28977b7bd81bea19d
Quelldatensatz
uspto-grants-2009_03
Patentnummer
US07504508B2

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