Sodium Hydroxide → HCID 178493213, Verbindung

HRID 1786727Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1786727
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][N:6]=[C:7]([CH2:11][S+:12]([O-:26])[C:13]2[NH:14][C:15]3[CH:16]=[CH:17][C:18]([O:22][CH:23]([F:25])[F:24])=[CH:19][C:20]=3[N:21]=2)[C:8]=1[O:9][CH3:10].[OH-].[Na+:28]>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][N:6]=[C:7]([CH2:11][S+:12]([O-:26])[C:13]2[N-:14][C:15]3[CH:16]=[CH:17][C:18]([O:22][CH:23]([F:24])[F:25])=[CH:19][C:20]=3[N:21]=2)[C:8]=1[O:9][CH3:10].[Na+:28]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 178493214Pantoprazole

Produkt 1

HCID 178493213HCID 178493213, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A 100 ml flask was charged with toluene (50.0 ml). Pantoprazole (5.0 g, 12.8 mmol) and 47% aqueous NaOH (1.2 g) were added to the stirred solvent at room temperature. The mixture was stirred until dissolution and then overnight until precipitation. The solid was filtered giving pantoprazole sodium. The sample was dried at 45° C. under 10 mm Hg vacuum overnight, giving 4.21 g of amorphous pantoprazole sodium.

Aufarbeitung

  1. customovernight until precipitation
  2. filtrationThe solid was filtered

Quellen und Nachweise

ORD-Eintrag
ord-accc83431eda449d8f9bf1d3f65d93f7
Quelldatensatz
uspto-grants-2009_03
Patentnummer
US07507829B2

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