Hydrochloric Acid → HCID 67521251, Verbindung

HRID 1786949Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1786949
C(OC(=O)[NH:7][CH2:8][C:9]1[NH:17][C:16]2[C:15]([NH:18][C:19]3[CH:24]=[CH:23][C:22]([O:25][CH2:26][C:27]4[CH:32]=[CH:31][CH:30]=[C:29]([F:33])[CH:28]=4)=[C:21]([Cl:34])[CH:20]=3)=[N:14][CH:13]=[N:12][C:11]=2[CH:10]=1)(C)(C)C.[ClH:36].C(O)C>O1CCCC1>[ClH:34].[ClH:36].[NH2:7][CH2:8][C:9]1[NH:17][C:16]2[C:15]([NH:18][C:19]3[CH:24]=[CH:23][C:22]([O:25][CH2:26][C:27]4[CH:32]=[CH:31][CH:30]=[C:29]([F:33])[CH:28]=4)=[C:21]([Cl:34])[CH:20]=3)=[N:14][CH:13]=[N:12][C:11]=2[CH:10]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 86626249Carbamic acid, N-[[4-[[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-5H-pyrrolo[3,2-d]pyrimidin-6-yl]methyl]-, 1,1-dimethylethyl ester

Produkt 1

HCID 67521251HCID 67521251, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

To a solution of tert-butyl[4-({3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)-5H-pyrrolo[3,2-d]pyrimidin-6-yl]methylcarbamate (500 mg) in tetrahydrofuran (12 mL) was added 2N hydrochloric acid (6.0 mL) at room temperature. The mixture was stirred at 60° C. for 2 hrs, ethanol was added to the reaction system and the mixture was concentrated under reduced pressure. The resultant crystals were collected by filtration and washed with diisopropyl ether to give the title compound (481.4 mg) as pale-yellow powder crystals.

Aufarbeitung

  1. concentrationthe mixture was concentrated under reduced pressure
  2. filtrationThe resultant crystals were collected by filtration
  3. washwashed with diisopropyl ether

Quellen und Nachweise

ORD-Eintrag
ord-df99aae6eb6d4398afa663d1b74d2106
Quelldatensatz
uspto-grants-2009_03
Patentnummer
US07507740B2

Notizen zur Reaktion

Wird geladen…