N-bromobutanimide → 6-bromo-4-pentyl-4,7-dihydro-8H-tetrazolo[1,5-a]purin-8-one

HRID 1787792Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1787792
[CH2:1]([N:6]1[C:14]2[N:13]=[CH:12][NH:11][C:10]=2[C:9](=[O:15])[N:8]2[N:16]=[N:17][N:18]=[C:7]12)[CH2:2][CH2:3][CH2:4][CH3:5].C1C(=O)N([Br:26])C(=O)C1>C1COCC1>[Br:26][C:12]1[NH:11][C:10]2[C:9](=[O:15])[N:8]3[N:16]=[N:17][N:18]=[C:7]3[N:6]([CH2:1][CH2:2][CH2:3][CH2:4][CH3:5])[C:14]=2[N:13]=1

Komponenten

4

Edukt 2

HCID 67184N-bromobutanimideHCID 576002974-pentyl-4,7-dihydro-8H-tetrazolo[1,5-a]purin-8-one

Produkt 1

HCID 250596546-bromo-4-pentyl-4,7-dihydro-8H-tetrazolo[1,5-a]purin-8-oneAusbeute 13,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

The mixture of 4-pentyl-4,7-dihydro-8H-tetrazolo[1,5-a]purin-8-one (94.6 mg, 0.38 mmol) and NBS (75 mg, 0.42 mmol) in THF (20 ml) was stirred at 70° C. for 1 hour. After evaporation of solvent, the residue was purified by preparative LC-MS to yield the desired product (17.1 mg, 13.7%). LCMS calculated for C10H13BrN7O(M+H): 326.0; found: 326.0.

Aufarbeitung

  1. customAfter evaporation of solvent
  2. customthe residue was purified by preparative LC-MS

Quellen und Nachweise

ORD-Eintrag
ord-51d144eb104145759652ecd78e3a16f8
Quelldatensatz
uspto-grants-2009_03
Patentnummer
US07511050B2

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