HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Sodium Hydroxide → 4-(Piperidine-1-sulfonyl)aniline
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Sodium Hydroxide | HCID 14798 | — |
| Edukt | N-(4-(1-Piperidinylsulfonyl)phenyl)acetamide | HCID 79780 | — |
| Edukt | Dichloromethane ethylacetate | HCID 21226138 | — |
| Lösungsmittel | Hydrochloric Acid | HCID 313 | — |
| Produkt | 4-(Piperidine-1-sulfonyl)aniline | HCID 236648 | 70,62% |
Reaktionsschritte
N-[4-(Acetylamino)phenylsulfonyl]piperidine (Example 5) was heated at 100° C. in 20% hydrochloric acid (5 mL) for one hour (TLC ethyl acetate/dichloromethane 8:2). The solution is neutralized at 0° C. with NaOH. The precipitate that forms is filtered and recrystallized from methanol/diethyl ether to afford the desired N-[4-(amino)phenylsulfonyl]piperidine. 70.62% yield; white solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07511133B2 |
| Quelldatensatz | uspto-grants-2009_03 |
| ORD ID | ord-72f5b3bac1774de1a6a19a42599f80db |
| Quellennotiz | uspto-grants-2009_03 |