Benzil → 1-Cyclohexyl-2-(2,3-diphenylquinoxalin-6-yl)benzimidazole-5-carboxylic acid

HRID 1788450Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1788450
[CH:1]1([N:7]2[C:11]3[CH:12]=[CH:13][C:14]([C:16]([OH:18])=[O:17])=[CH:15][C:10]=3[N:9]=[C:8]2[C:19]2[CH:24]=[CH:23][C:22]([NH2:25])=[C:21]([NH2:26])[CH:20]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:27]1([C:33]([C:35]([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)=O)=O)[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[CH:1]1([N:7]2[C:11]3[CH:12]=[CH:13][C:14]([C:16]([OH:18])=[O:17])=[CH:15][C:10]=3[N:9]=[C:8]2[C:19]2[CH:20]=[C:21]3[C:22](=[CH:23][CH:24]=2)[N:25]=[C:35]([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)[C:33]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[N:26]3)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

3

Edukt 2

HCID 8651BenzilHCID 689222991-Cyclohexyl-2-(3,4-diaminophenyl)-1H-benzimidazole-5-carboxylic Acid

Produkt 1

HCID 52760271-Cyclohexyl-2-(2,3-diphenylquinoxalin-6-yl)benzimidazole-5-carboxylic acid

Versuchsvorschrift

A solution of 100 mg (0.29 mmol) of Compound 406b and 74 mg (0.35 mmol) of benzil was stirred at room temperature overnight. The solvent was evaporated and the residue was purified on preparative HPLC yielding 10 mg.

Aufarbeitung

  1. customThe solvent was evaporated
  2. customthe residue was purified on preparative HPLC
  3. customyielding 10 mg

Quellen und Nachweise

ORD-Eintrag
ord-afe93530b68c4c44afbddeeb0e91daec
Quelldatensatz
uspto-grants-2009_03
Patentnummer
US07511145B2

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