Hydrochloric Acid → 5-Amino-2-chloro-4-fluorophenylthioacetic acid

HRID 1788775Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1788775
C([NH:4][C:5]1[C:6]([F:16])=[CH:7][C:8]([Cl:15])=[C:9]([CH2:11][C:12]([OH:14])=[S:13])[CH:10]=1)(=O)C.Cl.[OH-].[Na+]>>[NH2:4][C:5]1[C:6]([F:16])=[CH:7][C:8]([Cl:15])=[C:9]([CH2:11][C:12]([OH:14])=[S:13])[CH:10]=1

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 1784742305-(N-acetylamino)-2-chloro-4-fluorophenylthioacetic acid

Produkt 1

HCID 1785076495-Amino-2-chloro-4-fluorophenylthioacetic acidAusbeute 73 %

Versuchsvorschrift

A suspension of 5-(N-acetylamino)-2-chloro-4-fluorophenylthioacetic acid (89.8 g) in a 10% aqueous hydrochloric acid solution was refluxed for 2 hours under heating. After being allowed to cool, an aqueous solution of sodium hydroxide was added to make the suspension at pH 4. After ice-cooling, the precipitated crystals were collected by filteration, washed with ice-water and dried to give 55.0 g of 5-amino-2-chloro-4-fluorophenylthioacetic acid.

Aufarbeitung

  1. temperaturewas refluxed for 2 hours
  2. temperatureunder heating
  3. temperatureto cool
  4. temperatureAfter ice-cooling
  5. customthe precipitated crystals were collected by filteration
  6. washwashed with ice-water
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-66918d79d0a84c83a3cb9be01a6051a0
Quelldatensatz
uspto-grants-1987_08
Patentnummer
US04684397

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