Reaktionsgleichung
[Cl:1][C:2]1[N:3]=[N:4][C:5]([S:8]([N:11](C2C=CC=CC=2)[C:12](=[O:14])[O-])(=[O:10])=[O:9])=[CH:6][CH:7]=1.[NH2:21][C:22]1[N:27]=[C:26]([O:28][CH3:29])[N:25]=[C:24]([CH3:30])[N:23]=1>O1CCOCC1>[Cl:1][C:2]1[N:3]=[N:4][C:5]([S:8]([NH:11][C:12]([NH:21][C:22]2[N:27]=[C:26]([O:28][CH3:29])[N:25]=[C:24]([CH3:30])[N:23]=2)=[O:14])(=[O:9])=[O:10])=[CH:6][CH:7]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A mixture of 14.2 g of N-(3-chloropyridazine-6-sulfonyl)phenylcarbamate and 6.3 g of 2-amino-4-methoxy-6-methyl-1,3,5-triazine are refluxed for 1 hour in 120 ml of absolute dioxan. When the reaction is complete, the mixture is concentrated in vacuo and the residue is taken up in a saturated aqueous solution of sodium bicarbonate and the insoluble constituents are extracted with methylene chloride. The aqueous phase is acidified with dilute hydrochloric acid and extracted with methylene chloride. The methylene chloride solution is dried over sodium sulfate and concentrated, affording 7 g of the compound of the above formula with a melting point of 135° C.
Aufarbeitung
- concentrationthe mixture is concentrated in vacuo
- extractionthe insoluble constituents are extracted with methylene chloride
- extractionextracted with methylene chloride
- dry with materialThe methylene chloride solution is dried over sodium sulfate
- concentrationconcentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-ae4597ad267b47eb9940dcaad6564230
- Quelldatensatz
- uspto-grants-1987_08
- Patentnummer
- US04684730
Verknüpfte Notizen
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