1-Piperazinecarboxylic acid, ethyl ester → 4-(1,4-Dihydro-3-methyl-1, 4-dioxo-2-naphthalenyl)-1-piperazinecarboxylic acid, ethyl ester

HRID 1788907

Reaktionsgleichung

Reaktionsgleichung von HRID 1788907
O1[C:11]2([CH3:12])[CH:2]1[C:3](=[O:14])[C:4]1[C:9]([C:10]2=[O:13])=[CH:8][CH:7]=[CH:6][CH:5]=1.[N:15]1([C:21]([O:23][CH2:24][CH3:25])=[O:22])[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1>C(O)C>[CH3:12][C:11]1[C:10](=[O:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3](=[O:14])[C:2]=1[N:18]1[CH2:17][CH2:16][N:15]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[CH2:20][CH2:19]1

Komponenten

4

Edukt 2

HCID 84311-Piperazinecarboxylic acid, ethyl esterHCID 858452,3-Epoxy-2-methyl-1,4-naphthoquinone

Produkt 1

HCID 142787654-(1,4-Dihydro-3-methyl-1, 4-dioxo-2-naphthalenyl)-1-piperazinecarboxylic acid, ethyl esterAusbeute 30,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

A mixture of 1.88 g of 2,3-epoxy-3-methyl-1,4-naphthoquinone, 3.16 g of piperazinecarboxylic acid, ethyl ester and 100 ml of absolute ethanol was stirred for 12 hours at 50° C. The solvent was then removed and the remainder filtered through a one inch plug of silica gel and eluted with chloroform. The eluate was evaporated, giving 1 g of the desired product as a viscous red oil.

Aufarbeitung

  1. customThe solvent was then removed
  2. filtrationthe remainder filtered through a one inch plug of silica gel
  3. washeluted with chloroform
  4. customThe eluate was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-bd93f5c31e3a4d1182f4de13828044bc
Quelldatensatz
uspto-grants-1987_08
Patentnummer
US04686220

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