HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hydrochloric Acid → 2-Nitro-4-benzoylphenylacetic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hydrochloric Acid | HCID 313 | — |
| Edukt | Diethyl 2-nitro-4-benzoylphenylmalonate | HCID 13408230 | — |
| Lösungsmittel | 1,4-Dioxane | HCID 31275 | — |
| Produkt | 2-Nitro-4-benzoylphenylacetic acid | HCID 13770536 | 95% |
Reaktionsschritte
A mixture of 14 g. (36.3 mmoles) of diethyl 2-nitro-4-benzoylphenylmalonate, 300 ml. of 4N hydrochloric acid and 300 ml. of dioxane was heated to reflux for 10 hours. The reaction mixture was concentrated in vacuo and the crude product was triturated with hot methylene chloride, 9.88 g. (95% yield), m.p. 168°-170° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04686224 |
| Quelldatensatz | uspto-grants-1987_08 |
| ORD ID | ord-abaea9c2d3f2432c870e6577b3d1cda8 |
| Quellennotiz | uspto-grants-1987_08 |