Hydrochloric Acid → (4-Methoxy-6-Methyl-2-pyriMidinyl)thiourea, 97+%

HRID 1789287Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1789287
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[N:6]=[C:5]([NH:10][C:11]([NH:13]NC(=O)C2C=CC=CC=2)=[S:12])[N:4]=1.[OH-].[Na+].Cl>>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[N:6]=[C:5]([NH:10][C:11]([NH2:13])=[S:12])[N:4]=1

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 54321636HCID 54321636, Verbindung

Produkt 1

HCID 939981(4-Methoxy-6-Methyl-2-pyriMidinyl)thiourea, 97+%Ausbeute 102,5 %

Versuchsvorschrift

A mixture of 25 g of the compound from Example 3 and 55 ml of 10% aqueous sodium hydroxide was heated on the steam bath for 30 minutes, cooled, neutralized with aqueous HCl to pH 8, filtered, washed with water, dried by suction, and washed with ether to afford 16 g of the title compound, m.p. 220° d.

Aufarbeitung

  1. temperaturewas heated on the steam bath for 30 minutes
  2. temperaturecooled
  3. filtrationfiltered
  4. washwashed with water
  5. customdried by suction
  6. washwashed with ether

Quellen und Nachweise

ORD-Eintrag
ord-a40805c7071b481f815b33baed5200e6
Quelldatensatz
uspto-grants-1987_08
Patentnummer
US04689070

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