2-Acetylsulfanylmethyl-3-(6-amino-5-methyl-pyridin-3-yl)-2-methyl-propionic acid ethyl ester → 3-(6-Amino-5-methyl-pyridin-3-yl)-2-mercaptomethyl-2-methyl-propionic acid

HRID 1789824Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1789824
C([O:3][C:4](=[O:21])[C:5]([CH2:16][S:17]C(=O)C)([CH3:15])[CH2:6][C:7]1[CH:8]=[N:9][C:10]([NH2:14])=[C:11]([CH3:13])[CH:12]=1)C>Cl>[NH2:14][C:10]1[N:9]=[CH:8][C:7]([CH2:6][C:5]([CH2:16][SH:17])([CH3:15])[C:4]([OH:21])=[O:3])=[CH:12][C:11]=1[CH3:13]

Komponenten

3

Edukt 1

HCID 572012572-Acetylsulfanylmethyl-3-(6-amino-5-methyl-pyridin-3-yl)-2-methyl-propionic acid ethyl ester

Produkt 1

HCID 101986553-(6-Amino-5-methyl-pyridin-3-yl)-2-mercaptomethyl-2-methyl-propionic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

2-Acetylsulfanylmethyl-3-(6-amino-5-methyl-pyridin-3-yl)-2-methyl-propionic acid ethyl ester (17 mg, 40 μmol) was dissolved in conc. HCl (2 mL) under argon. The solution was heated to reflux for 150 min. Concentration under reduced pressure gave the title compound as the hydrochloride salt (10.7 mg, 96%).

Aufarbeitung

  1. temperatureThe solution was heated
  2. temperatureto reflux for 150 min
  3. concentrationConcentration under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-b962369971ea4d278e8a5ef08961e63a
Quelldatensatz
uspto-grants-2006_07
Patentnummer
US07071175B1

Notizen zur Reaktion

Wird geladen…