2-Acetylsulfanylmethyl-3-(6-tert-butoxycarbonylamino-pyridin-3-yl)-3-phenyl-propionic acid ethyl ester → 3-(6-Amino-pyridin-3-yl)-2-mercaptomethyl-3-phenyl-propionic acid

HRID 1789915Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1789915
C([O:3][C:4](=[O:32])[CH:5]([CH2:27][S:28]C(=O)C)[CH:6]([C:13]1[CH:14]=[N:15][C:16]([NH:19]C(OC(C)(C)C)=O)=[CH:17][CH:18]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)C>Cl>[NH2:19][C:16]1[N:15]=[CH:14][C:13]([CH:6]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:5]([CH2:27][SH:28])[C:4]([OH:32])=[O:3])=[CH:18][CH:17]=1

Komponenten

3

Edukt 1

HCID 539704052-Acetylsulfanylmethyl-3-(6-tert-butoxycarbonylamino-pyridin-3-yl)-3-phenyl-propionic acid ethyl ester

Produkt 1

HCID 220361473-(6-Amino-pyridin-3-yl)-2-mercaptomethyl-3-phenyl-propionic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

2-Acetylsulfanylmethyl-3-(6-tert-butoxycarbonylamino-pyridin-3-yl )-3-phenyl-propionic acid ethyl ester (58 mg, 0.125 mmol) was dissolved in conc. HCl (3.0 mL). The solution was heated to reflux for 130 min under argon. Concentration under reduced pressure gave the title compound as the hydrochloride salt (41 mg, 100%).

Aufarbeitung

  1. temperatureThe solution was heated
  2. temperatureto reflux for 130 min under argon
  3. concentrationConcentration under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-17582d8f0b60422395c84343561351ad
Quelldatensatz
uspto-grants-2006_07
Patentnummer
US07071175B1

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