2,4-Difluorophenethyl bromide → 1-[1-(2,4-Difluorophenethyl)-piperdin-4-yl]-6-bromoindoline
Reaktionsgleichung
[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([Br:16])[CH:14]=3)[CH2:9][CH2:8]2)[CH2:3][CH2:2]1.[F:17][C:18]1[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:19]=1[CH2:20][CH2:21]Br>>[F:17][C:18]1[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:19]=1[CH2:20][CH2:21][N:1]1[CH2:6][CH2:5][CH:4]([N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([Br:16])[CH:14]=3)[CH2:9][CH2:8]2)[CH2:3][CH2:2]1Komponenten
3
Versuchsvorschrift
1-(Piperidin-4-yl)-6-bromoindoline (3.0 g) and 2,4-difluorophenethyl bromide (3.1 g) were treated as in Example 2 to give the title compound (2.7 g) as a white powder (yield: 60%).
Quellen und Nachweise
- ORD-Eintrag
- ord-232ee03a698e48479f56307e26524ce8
- Quelldatensatz
- uspto-grants-2006_07