6-(1-aminopropyl)-3-(3-nitrophenyl)-1,2,4-triazin-5(4H)-one → HCID 178457784, Verbindung
Reaktionsgleichung
[NH2:1][CH:2]([C:5]1[C:6](=[O:20])[NH:7][C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([N+:17]([O-:19])=[O:18])[CH:12]=2)=[N:9][N:10]=1)[CH2:3][CH3:4].[C:21]([C@@H:25]1[CH2:30][CH2:29][C@H:28]([C:31](Cl)=[O:32])[CH2:27][CH2:26]1)([CH3:24])([CH3:23])[CH3:22]>>[C:21]([C@@H:25]1[CH2:26][CH2:27][C@H:28]([C:31]([NH:1][CH:2]([C:5]2[C:6](=[O:20])[NH:7][C:8]([C:11]3[CH:16]=[CH:15][CH:14]=[C:13]([N+:17]([O-:19])=[O:18])[CH:12]=3)=[N:9][N:10]=2)[CH2:3][CH3:4])=[O:32])[CH2:29][CH2:30]1)([CH3:24])([CH3:22])[CH3:23]Komponenten
3
Versuchsvorschrift
In analogy to the procedure for Example 16A, 3.2 g (11.6 mmol) 6-(1-aminopropyl)-3-(3-nitrophenyl)-1,2,4-triazin-5(4H)-one (Example 15A), 2.4 g (11.6 mmol) cis-4-tert.-butylcyclohexanecarbonyl chloride (Example 42A) and proportionate amounts of the other reagents are used. The crude product is used in the next step without further purification.
Aufarbeitung
- customThe crude product is used in the next step without further purification