2,6-Lutidine → 7-Bromo-4-chloro-2-(chloromethyl)quinazoline

HRID 1791249Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1791249
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=O)[NH:7][C:8]([CH2:12][Cl:13])=[N:9]2)=[CH:4][CH:3]=1.N1C(C)=CC=CC=1C.P(Cl)(Cl)([Cl:25])=O>COCCOC>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([Cl:25])=[N:7][C:8]([CH2:12][Cl:13])=[N:9]2)=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 79372,6-LutidineHCID 24813Phosphorus oxychlorideHCID 1356820607-Bromo-2-(chloromethyl)quinazolin-4-ol

Produkt 1

HCID 220301087-Bromo-4-chloro-2-(chloromethyl)quinazoline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 80711,2-DimethoxyethaneLösungsmittel

Versuchsvorschrift

Heat a mixture of 7-bromo-2-chloromethyl-3H-quinazolin-4-one (5 g, 18.2 mmol), 2,6-lutidine (5 g), and phosphorus oxychloride (5 mL) in 1,2-dimethoxyethane (500 mL) at 80° C. for 16 hours. Cool the mixture to room temperature and fully evaporate the mixture, then dilute with ether and wash with water. Dry the solvent (Na2SO4) and evaporate the ether to obtain 7-bromo-4-chloro-2-chloromethylquinazoline (3.5 g) as a yellow solid.

Aufarbeitung

  1. temperatureHeat
  2. customfully evaporate the mixture
  3. additiondilute with ether
  4. washwash with water
  5. dry with materialDry the solvent (Na2SO4)
  6. customevaporate the ether

Quellen und Nachweise

ORD-Eintrag
ord-d14c368a73f7413183370a1f21e7e743
Quelldatensatz
uspto-grants-2006_07
Patentnummer
US07074799B2

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