Trifluoroacetic acid → [7-(2-Butynyl)-2,6-dioxo-8-(piperazin-1-yl)-1,2,6,7-tetrahydropurin-3-yl] acetic acid methyl ester trifluoroacetate

HRID 1792063Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1792063
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:22]([CH2:23][C:24]#[C:25][CH3:26])[C:21]3[C:20](=[O:27])[NH:19][C:18](=[O:28])[N:17]([CH2:29][C:30]([O:32][CH3:33])=[O:31])[C:16]=3[N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[F:34][C:35]([F:40])([F:39])[C:36]([OH:38])=[O:37]>>[F:34][C:35]([F:40])([F:39])[C:36]([OH:38])=[O:37].[CH3:33][O:32][C:30](=[O:31])[CH2:29][N:17]1[C:16]2[N:15]=[C:14]([N:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)[N:22]([CH2:23][C:24]#[C:25][CH3:26])[C:21]=2[C:20](=[O:27])[NH:19][C:18]1=[O:28]

Komponenten

3

Edukt 2

HCID 6422Trifluoroacetic acidHCID 235369464-[7-(2-Butynyl)-3-methoxycarbonylmethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]piperazine-1-carboxylic acid tert-butyl ester

Produkt 1

HCID 69566880[7-(2-Butynyl)-2,6-dioxo-8-(piperazin-1-yl)-1,2,6,7-tetrahydropurin-3-yl] acetic acid methyl ester trifluoroacetate

Versuchsvorschrift

4-[7-(2-Butynyl)-3-methoxycarbonylmethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]piperazine-1-carboxylic acid tert-butyl ester (13 mg) was dissolved in trifluoroacetic acid (0.5 ml), and the solution was stirred at room temperature for 30 minutes. After the solvent was removed by distillation, a half of the residue was purified by HPLC with a reversed phase system column using water-acetonitrile-trifluoroacetic acid system as elution solvent to give 2.4 mg of the title compound.

Aufarbeitung

  1. customAfter the solvent was removed by distillation
  2. customa half of the residue was purified by HPLC with a reversed phase system column
  3. washas elution solvent

Quellen und Nachweise

ORD-Eintrag
ord-d474136064c3418089ffd13c09f942de
Quelldatensatz
uspto-grants-2006_07
Patentnummer
US07074798B2

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