Trifluoroacetic acid → N,N-Dimethyl-4-[6-(3-methyl-1H-4-pyrazolyl)-4-quinolyl]-1-piperazine sulfonamide

HRID 1792569Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1792569
[CH3:1][N:2]([CH3:47])[S:3]([N:6]1[CH2:11][CH2:10][N:9]([C:12]2[C:21]3[C:16](=[CH:17][CH:18]=[C:19]([C:22]4[C:23]([CH3:46])=[N:24][N:25](C(C5C=CC=CC=5)(C5C=CC=CC=5)C5C=CC=CC=5)[CH:26]=4)[CH:20]=3)[N:15]=[CH:14][CH:13]=2)[CH2:8][CH2:7]1)(=[O:5])=[O:4].FC(F)(F)C(O)=O>>[CH3:1][N:2]([CH3:47])[S:3]([N:6]1[CH2:11][CH2:10][N:9]([C:12]2[C:21]3[C:16](=[CH:17][CH:18]=[C:19]([C:22]4[C:23]([CH3:46])=[N:24][NH:25][CH:26]=4)[CH:20]=3)[N:15]=[CH:14][CH:13]=2)[CH2:8][CH2:7]1)(=[O:4])=[O:5]

Komponenten

3

Edukt 2

HCID 6422Trifluoroacetic acidHCID 23537796N,N-dimethyl-4-[6-(3-methyl-1-trityl-1H-pyrazolyl)-4-quinolyl]-1-piperazine sulfonamide

Produkt 1

HCID 178434512N,N-Dimethyl-4-[6-(3-methyl-1H-4-pyrazolyl)-4-quinolyl]-1-piperazine sulfonamideAusbeute 69,4 %

Versuchsvorschrift

37 mg N,N-dimethyl-4-[6-(3-methyl-1-trityl-1H-pyrazolyl)-4-quinolyl]-1-piperazine sulfonamide obtained in Example 183 and 0.2 mL trifluoroacetic acid were reacted in the same manner as in Example 165, to give 16 mg of the title compound as pale yellow crystals.

Quellen und Nachweise

ORD-Eintrag
ord-10d1169e32a1472798369eb75577d4b3
Quelldatensatz
uspto-grants-2006_07
Patentnummer
US07074801B1

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