Propylamine → 2,4-dichloro-N-propylbenzenesulfonamide

HRID 1792769Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1792769
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[S:9](Cl)(=[O:11])=[O:10].[CH2:13]([NH2:16])[CH2:14][CH3:15]>C(O)CCC>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[S:9](=[O:11])(=[O:10])[NH:16][CH2:13][CH2:14][CH3:15]

Komponenten

4

Edukt 2

HCID 7852PropylamineHCID 204419Benzenesulfonyl chloride, 2,4-dichloro-

Produkt 1

HCID 220249232,4-dichloro-N-propylbenzenesulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 2631-ButanolLösungsmittel

Versuchsvorschrift

2,4-Dichlorobenzenesulphonyl chloride (500 mg 2.1 mmol) and 1-propylamine (0.2 ml, 2.4 mmol) in n-butanol (10 ml) was heated at reflux for 48 hours. The volatiles were removed by evaporation and the residue triturated with diethylene ether and the product collected by filtration to give the title compound. NMR: 0.78 (t, 3H), 1.35 (q, 2H), 2.79 (t, 2H), 7.60 (dd, 1H), 7.84 (d, 1H), 7.92 (d, 2H)

Aufarbeitung

  1. temperatureat reflux for 48 hours
  2. customThe volatiles were removed by evaporation
  3. customthe residue triturated with diethylene ether
  4. filtrationthe product collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-c1cc11ebbe0d4252bbb59040cd5dbc06
Quelldatensatz
uspto-grants-2006_07
Patentnummer
US07078410B2

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