Dimethylformamide → HCID 22024515, Verbindung

HRID 1793065Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1793065
[Cl:1][C:2]1[C:3]2[N:4]([CH:8]=[C:9]([CH2:11][CH3:12])[N:10]=2)[CH:5]=[CH:6][N:7]=1.P(Cl)(Cl)(Cl)=O.CN(C)[CH:20]=[O:21]>>[Cl:1][C:2]1[C:3]2[N:4]([C:8]([CH:20]=[O:21])=[C:9]([CH2:11][CH3:12])[N:10]=2)[CH:5]=[CH:6][N:7]=1

Komponenten

4

Edukt 3

HCID 6228DimethylformamideHCID 24813Phosphorus oxychlorideHCID 120740798-Chloro-2-ethylimidazo[1,2-a]pyrazine

Produkt 1

HCID 22024515HCID 22024515, Verbindung

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

8-Chloro-2-ethylimidazo[1,2-a]pyrazine (600 mg, 3.3 mmol) was dissolved in N,N-dimethylformamide (3.3 mL), phosphorus oxychloride (1.2 mL, 13.2 mmol) was added dropwise at room temperature, and the mixture was heated under stirring at 90° C. for 2 hours. After being allowed to cool, the reaction mixture was poured into ice and extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and evaporated to give the title compound (472 mg) as white crystals.

Aufarbeitung

  1. temperaturethe mixture was heated
  2. temperatureto cool
  3. additionthe reaction mixture was poured into ice
  4. extractionextracted with ethyl acetate
  5. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  6. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-e51d2344008247c5826386b93d8b5392
Quelldatensatz
uspto-grants-2006_07
Patentnummer
US07078405B2

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