Thionyl Chloride → HCID 22024658, Verbindung

HRID 1793084Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1793084
[Br:1][C:2]1[C:3]([NH:8][CH:9]([CH2:12][CH3:13])[CH2:10]O)=[N:4][CH:5]=[N:6][CH:7]=1.S(Cl)(Cl)=O>C1(C)C(C)=CC=CC=1>[Br:1][C:2]1[C:3]2[N:4]([CH2:10][CH:9]([CH2:12][CH3:13])[N:8]=2)[CH:5]=[N:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 22024679HCID 22024679, Verbindung

Produkt 1

HCID 22024658HCID 22024658, VerbindungAusbeute 98,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7237O-XyleneLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

2-[(5-Bromo-4-pyrimidinyl)amino]-1-butanol (3.3 g) was dissolved in xylene (27 mL), then thionyl chloride (4.9 mL) was added thereto, and the mixture was heated under stirring at 100° C. for 1 day. The precipitated crystals were collected by filtration and suspended in a 1M aqueous sodium carbonate solution. This mixture was extracted with dichloromethane to give the crude title compound (3.0 g) as an orange oil. This title compound was used in the next reaction without purification.

Aufarbeitung

  1. temperaturethe mixture was heated
  2. filtrationThe precipitated crystals were collected by filtration
  3. extractionThis mixture was extracted with dichloromethane

Quellen und Nachweise

ORD-Eintrag
ord-5ce564191dcc48cfa674d17d783155ab
Quelldatensatz
uspto-grants-2006_07
Patentnummer
US07078405B2

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