2,4-Dimethylbenzyl alcohol → 2,4-Dimethylbenzyl cis-2,6-dimethylpiperazine-1-carboxylate hydrochloride

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Reaktionsschritte

2,4-Dimethylbenzyl cis-2,6-dimethylpiperazine-1-carboxylate hydrochloride was prepared from cis 1-chlorocarbonyl-2,6-dimethyl-4-tert-butoxycarbonylpiperazine and 2,4-dimethylbenzyl alcohol according to the methods described for Examples 52 and 54 to give the product as a hygroscopic white solid (0.1384 g, 44% overall); (Found: C, 60.9; H, 8.1; N, 8.9%. C16H24N2O2.HCl.0.25H2O requires C, 60.6; H, 8.1; N, 8.8%); δH (400 MHz, DMSO-d6) 9.53 (2H, br), 7.19 (1H, d, J 7.6 Hz), 7.03 (1H, s), 6.99 (1H, d, J 7.6 Hz), 5.07 (2H, s), 4.29 (2H, m), 3.13 (2H, d, J 13.2 Hz), 3.04 (2H, dd, J 5.2 and 13.2 Hz), 2.27 (3H, s), 2.26 (3H, s) and 1.29 (6H, d, J 7.2 Hz).

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