1-Iodopropane → HCID 21021911, Verbindung

HRID 1794110

Reaktionsgleichung

Reaktionsgleichung von HRID 1794110
[F:1][C:2]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][C:3]=1[CH2:4][OH:5].I[CH2:12][CH2:13][CH3:14].[C:15]([OH:22])(=[O:21])/[CH:16]=[CH:17]/[C:18]([OH:20])=[O:19].[CH2:23]([C@@H:25]1[CH2:30][NH:29][CH2:28][CH2:27][N:26]1[C:31](OCC1C=CC(OC(F)F)=CC=1)=[O:32])C>>[C:15]([OH:22])(=[O:21])/[CH:16]=[CH:17]/[C:18]([OH:20])=[O:19].[CH3:23][C@@H:25]1[CH2:30][NH:29][CH2:28][CH2:27][N:26]1[C:31]([O:5][CH2:4][C:3]1[CH:6]=[C:7]([O:10][CH2:12][CH2:13][CH3:14])[CH:8]=[CH:9][C:2]=1[F:1])=[O:32]

Komponenten

4

Edukt 3

HCID 336431-IodopropaneHCID 21021913(R)-4-Difluoromethoxybenzyl 2-ethylpiperazine-1-carboxylate fumarateHCID 691416144-Fluoro-3-(hydroxymethyl)phenol

Produkt 1

HCID 21021911HCID 21021911, Verbindung

Versuchsvorschrift

(R)-2-Fluoro-5-propoxybenzyl 2-methylpiperazine-1-carboxylate fumarate was prepared from 2-fluoro-5-hydroxybenzyl alcohol, 1-iodopropane and (R) 1-chlorocarbonyl-2-methyl-4-tert-butoxycarbonylpiperazine according to the methods described for Examples 54 and 96 to give the product as a white solid (26.4%); melting point 162.6–162.7° C.; NMR δH (400 MHz, DMSO-d6) 0.963(3H, t, J 7.5 Hz), 1.173(3H, d, J 7.0 Hz), 1.709(2H, m), 2.582(1H, m), 2.801(2H, bs), 2.991(2H, bm), 3.731(1H, bdd), 3.895(2H, t, J 6.5 Hz), 4.142(1H, bm), 5.077(2H,q), 6.556(2H, s), 6.931(2H, m) and 7.126(1H, t, J 9.0 Hz).

Quellen und Nachweise

ORD-Eintrag
ord-0b532320098d405d95201d3b7e9103f0
Quelldatensatz
uspto-grants-2006_04
Patentnummer
US07022707B2

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