Hydrogen chloride-ethyl acetate → HCID 69663689, Verbindung

HRID 1794226Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1794226
[CH2:1]([O:3][C:4]([C@@H:6]1[O:11][C:10]2[CH:12]=[CH:13][C:14]([CH2:16][C@H:17]([NH:19][CH2:20][C@H:21]([OH:41])[CH2:22][O:23][C:24]3[CH:29]=[C:28]([O:30][CH3:31])[C:27]([O:32]COC)=[C:26]([NH:36][S:37]([CH3:40])(=[O:39])=[O:38])[CH:25]=3)[CH3:18])=[CH:15][C:9]=2[O:8][CH2:7]1)=[O:5])[CH3:2].[ClH:42].CCOC(C)=O>C(O)C>[ClH:42].[CH2:1]([O:3][C:4]([C@@H:6]1[O:11][C:10]2[CH:12]=[CH:13][C:14]([CH2:16][C@H:17]([NH:19][CH2:20][C@H:21]([OH:41])[CH2:22][O:23][C:24]3[CH:29]=[C:28]([O:30][CH3:31])[C:27]([OH:32])=[C:26]([NH:36][S:37]([CH3:40])(=[O:38])=[O:39])[CH:25]=3)[CH3:18])=[CH:15][C:9]=2[O:8][CH2:7]1)=[O:5])[CH3:2]

Komponenten

4

Edukt 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 58618751HCID 58618751, Verbindung

Produkt 1

HCID 69663689HCID 69663689, VerbindungAusbeute 101,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of 6-[2-(R)-[2-(S)-hydroxy-3-[3-methanesulfonamido-5-methoxy-4-(methoxymethoxy)phenoxy]-propylamino]propyl]-2,3-dihydro-1,4-benzodioxine-2-(R)-carboxylic acid ethyl ester (100 mg) obtained in Example 26 in ethanol (10 mL) was added 4N—HCl/AcOEt (1.0 mL, 4.0 mmol) at room temperature. This solution was stirred at room temperature for 16 hours and then concentrated to dryness under reduced pressure, affording the title compound (100 mg). Yield: 85%

Aufarbeitung

  1. concentrationconcentrated to dryness under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-7daf66e0efb344eabcd7e33ab30120ca
Quelldatensatz
uspto-grants-2006_04
Patentnummer
US07022732B2

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