(Butylamino)acetonitrile → N-Butyl-N-(cyanomethyl)-4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)benzamide

HRID 1794812

Reaktionsgleichung

Reaktionsgleichung von HRID 1794812
[O:1]1[C:5]2([CH2:10][CH2:9][N:8]([C:11]3[CH:19]=[CH:18][C:14]([C:15](O)=[O:16])=[CH:13][CH:12]=3)[CH2:7][CH2:6]2)[O:4][CH2:3][CH2:2]1.[CH2:20]([NH:24][CH2:25][C:26]#[N:27])[CH2:21][CH2:22][CH3:23]>>[CH2:20]([N:24]([CH2:25][C:26]#[N:27])[C:15](=[O:16])[C:14]1[CH:18]=[CH:19][C:11]([N:8]2[CH2:9][CH2:10][C:5]3([O:4][CH2:3][CH2:2][O:1]3)[CH2:6][CH2:7]2)=[CH:12][CH:13]=1)[CH2:21][CH2:22][CH3:23]

Komponenten

3

Edukt 2

HCID 76373(Butylamino)acetonitrileHCID 159484254-(1,4-Dioxa-8-aza-spiro[4.5]dec-8-yl)-benzoic acid

Produkt 1

HCID 22220389N-Butyl-N-(cyanomethyl)-4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)benzamide

Versuchsvorschrift

The title compound was prepared from 4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-benzoic acid (which was obtained in Example 150) (0.37 g, 1.4 mmol) and (n-butylamino)acetonitrile (0.48 g, 4.2 mmol) according to the procedure shown for Example 154 to give 0.52 g of an amber gum; MS (ES) m/z: 358.3 (MH+); HRMS (ES) Calcd. for C20H28N3O3 (MH+): 358.2125. Found: 358.2120.

Quellen und Nachweise

ORD-Eintrag
ord-7442b8e81df444f5bba1400790a2f77d
Quelldatensatz
uspto-grants-2006_04
Patentnummer
US07022716B2

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