Methanol → HCID 178497357, Verbindung
Reaktionsgleichung
[Cl:1][CH2:2][C:3]1[NH:7][C:6]2[CH:8]=[CH:9][C:10]([C:12]([OH:14])=[O:13])=[CH:11][C:5]=2[N:4]=1.S(=O)(=O)(O)O.[CH3:20]O>>[Cl:1][CH2:2][C:3]1[NH:7][C:6]2[CH:8]=[CH:9][C:10]([C:12]([O:14][CH3:20])=[O:13])=[CH:11][C:5]=2[N:4]=1Komponenten
4
Versuchsvorschrift
To 2-(Chloromethyl)-1H-benzimidazole-5-carboxylic acid (4) (0.5 g; 2.4 mmole) suspended in anhydrous methanol (20 ml) was added dropwise Sulfuric acid (0.2 ml). The reaction mixture was maintained at reflux for 16 hours. The solvent was evaporated to give the crude oily product, which was purified by column chromatography (silica, 10% methanol: dichloromethane) to obtain 0.4 g (71% yield) of product 5.
Aufarbeitung
- temperatureThe reaction mixture was maintained
- temperatureat reflux for 16 hours
- customThe solvent was evaporated
- customto give the crude oily product, which
- customwas purified by column chromatography (silica, 10% methanol: dichloromethane)
Quellen und Nachweise
- ORD-Eintrag
- ord-868a4287ec894ad8a8a4bf6d592a44da
- Quelldatensatz
- uspto-grants-2006_04
- Patentnummer
- US07030150B2
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