Dimethylformamide → 4-(fluoromethyl)benzoyl Chloride
Reaktionsgleichung
[F:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7](O)=[O:8])=[CH:5][CH:4]=1.CN(C)C=O.S(Cl)([Cl:19])=O>C1C=CC=CC=1>[F:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([Cl:19])=[O:8])=[CH:5][CH:4]=1Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 40 °C
Versuchsvorschrift
4-(Fluoromethyl)benzoic acid (6.20 g) was dissolved in 30 ml of benzene, and 0.3 ml of N,N-dimethylformamide was added and then 4.4 ml of thionyl chloride was added dropwise. The mixture was stirred for 1 hour at 40° C. and then heated to reflux for another 1 hour. The solvent was distilled off under reduced pressure to provide 6.70 g of the objective compound as pale yellow oil.
Aufarbeitung
- temperatureheated
- temperatureto reflux for another 1 hour
- distillationThe solvent was distilled off under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-58d0cf61080f4dc185b62ffaa896f1cd
- Quelldatensatz
- uspto-grants-2006_04
- Patentnummer
- US07030143B2
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