Cyclopropanemethanamine → Methyl 4-[(cyclopropylmethyl)amino]-3-nitrophenylcarbamate

HRID 1796488Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1796488
F[C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:12])[O:10][CH3:11])=[CH:4][C:3]=1[N+:13]([O-:15])=[O:14].[CH:16]1([CH2:19][NH2:20])[CH2:18][CH2:17]1>C(O)C>[CH:16]1([CH2:19][NH:20][C:2]2[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:12])[O:10][CH3:11])=[CH:4][C:3]=2[N+:13]([O-:15])=[O:14])[CH2:18][CH2:17]1

Komponenten

4

Edukt 2

HCID 75646CyclopropanemethanamineHCID 3636899Methyl (4-fluoro-3-nitrophenyl)carbamate

Produkt 1

HCID 22181376Methyl 4-[(cyclopropylmethyl)amino]-3-nitrophenylcarbamate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

Following general procedure 2B: To methyl 4-fluoro-3-nitrophenylcarbamate (6.50 g, 30.35 mmol, from previous step) in 80% aqueous ethanol (100 mL) was added cyclopropanemethylamine (5.00 mL, 57,65 mmol) at room temperature. The reaction mixture was heated at 60° C. overnight. After the usual work up, the crude product, which precipitated out, was collected (8.21 g). MS (ESI) (M+H)+=266.

Aufarbeitung

  1. customAfter the usual work up, the crude product, which precipitated out
  2. customwas collected (8.21 g)

Quellen und Nachweise

ORD-Eintrag
ord-5c3187edb35b4e3d91100710c278924a
Quelldatensatz
uspto-grants-2006_04
Patentnummer
US07030139B2

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