Hydrazine → 1-Amino-3-methoxy-1H-pyrrole-2,4-dicarboxylic acid diethyl ester

HRID 1796623Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1796623
[CH2:1]([O:3][C:4]([C:6]1[N:7]([N:18]2C(=O)C3C(=CC=CC=3)C2=O)[CH:8]=[C:9]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[C:10]=1[O:11][CH3:12])=[O:5])[CH3:2].NN>CCO>[CH2:1]([O:3][C:4]([C:6]1[N:7]([NH2:18])[CH:8]=[C:9]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[C:10]=1[O:11][CH3:12])=[O:5])[CH3:2]

Komponenten

4

Edukt 2

HCID 9321HydrazineHCID 693272701-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-methoxy-1H-pyrrole-2,4-dicarboxylic acid diethyl ester

Produkt 1

HCID 129859111-Amino-3-methoxy-1H-pyrrole-2,4-dicarboxylic acid diethyl esterAusbeute 74,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 393D (0.58 g, 1.58 mmol) and NH2NH2 (60 μl, 2.21 mmol) in EtOH (5 ml) was stirred at rt overnight, filtered through Celite, the filtrate was concentrated and the residue was purified by silica gel flash column chromatography to give 393E (0.30 g, 75%) (0%-5% EtOAc—CH2Cl2).

Aufarbeitung

  1. filtrationfiltered through Celite
  2. concentrationthe filtrate was concentrated
  3. customthe residue was purified by silica gel flash column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-4f3ffa5678524a1a8aa0ce1e435ed189
Quelldatensatz
uspto-grants-2006_04
Patentnummer
US07030112B2

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