4-[9-(2,2,2-Trifluoroethylcarbamoyl)-9H-xanthen-9-yl]butyl bromide → 2-Benzyl-7-[4-[4-[9-(2,2,2-trifluoroethylcarbamoyl)-9H-xanthen-9-yl]butyl]piperazin-1-yl]-3,4-dihydro-2H-isoquinolin-1-one

HRID 1796754Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1796754
[CH2:1]([N:8]1[CH2:17][CH2:16][C:15]2[C:10](=[CH:11][C:12]([N:18]3[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]3)=[CH:13][CH:14]=2)[C:9]1=[O:31])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:32][C:33]([F:58])([F:57])[CH2:34][NH:35][C:36]([C:38]1([CH2:52][CH2:53][CH2:54][CH2:55]Br)[C:51]2[CH:50]=[CH:49][CH:48]=[CH:47][C:46]=2[O:45][C:44]2[C:39]1=[CH:40][CH:41]=[CH:42][CH:43]=2)=[O:37]>>[CH2:1]([N:8]1[CH2:17][CH2:16][C:15]2[C:10](=[CH:11][C:12]([N:18]3[CH2:23][CH2:22][N:21]([CH2:55][CH2:54][CH2:53][CH2:52][C:38]4([C:36](=[O:37])[NH:35][CH2:34][C:33]([F:58])([F:57])[F:32])[C:51]5[CH:50]=[CH:49][CH:48]=[CH:47][C:46]=5[O:45][C:44]5[C:39]4=[CH:40][CH:41]=[CH:42][CH:43]=5)[CH2:20][CH2:19]3)=[CH:13][CH:14]=2)[C:9]1=[O:31])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

3

Edukt 2

HCID 221802034-[9-(2,2,2-Trifluoroethylcarbamoyl)-9H-xanthen-9-yl]butyl bromideHCID 221804492-Benzyl-7-(4-t-butoxycarbonyl-piperazin-1-yl)-3,4-dihydro-2H-isoquinolin-1-one

Produkt 1

HCID 221802172-Benzyl-7-[4-[4-[9-(2,2,2-trifluoroethylcarbamoyl)-9H-xanthen-9-yl]butyl]piperazin-1-yl]-3,4-dihydro-2H-isoquinolin-1-one

Versuchsvorschrift

Step (b) of Example 97 was repeated, except that the compound prepared in step (a) of Example 97 and the compound prepared in step (a) of Example 96 were used. Thus, the title compound was prepared.

Quellen und Nachweise

ORD-Eintrag
ord-79a3a9e8299e4ac0bb4bed7b2642fc23
Quelldatensatz
uspto-grants-2006_04
Patentnummer
US07030120B2

Notizen zur Reaktion

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