2-benzyl-7-piperazinyl-2H-phthalazin-1-one → 2-Benzyl-7-[4-[3-[9-(2,2,2-trifluoroethylcarbamoyl)-9H-xanthen-9-yl]propyl]-piperazin-1-yl]-2H-phthalazin-1-one

HRID 1796773Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1796773
[F:1][C:2]([F:26])([F:25])[CH2:3][NH:4][C:5]([C:7]1([CH2:21][CH2:22][CH2:23]Br)[C:20]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[O:14][C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2)=[O:6].[CH2:27]([N:34]1[N:43]=[CH:42][C:41]2[C:36](=[CH:37][C:38]([N:44]3[CH2:49][CH2:48][NH:47][CH2:46][CH2:45]3)=[CH:39][CH:40]=2)[C:35]1=[O:50])[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>>[CH2:27]([N:34]1[N:43]=[CH:42][C:41]2[C:36](=[CH:37][C:38]([N:44]3[CH2:45][CH2:46][N:47]([CH2:23][CH2:22][CH2:21][C:7]4([C:5](=[O:6])[NH:4][CH2:3][C:2]([F:26])([F:25])[F:1])[C:20]5[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=5[O:14][C:13]5[C:8]4=[CH:9][CH:10]=[CH:11][CH:12]=5)[CH2:48][CH2:49]3)=[CH:39][CH:40]=2)[C:35]1=[O:50])[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1

Komponenten

3

Edukt 2

HCID 221802782-benzyl-7-piperazinyl-2H-phthalazin-1-oneHCID 221805833-[9-(2,2,2-Trifluoroethylcarbamoyl)-9H-xanthen-9-yl]propyl bromide

Produkt 1

HCID 221801742-Benzyl-7-[4-[3-[9-(2,2,2-trifluoroethylcarbamoyl)-9H-xanthen-9-yl]propyl]-piperazin-1-yl]-2H-phthalazin-1-one

Versuchsvorschrift

Step (c) of Example 92 was repeated, except that the compound prepared in step (b) of Example 114 and the compound prepared in step (e) of Example 137 were used as the starting compounds. Thus, the title compound was obtained.

Quellen und Nachweise

ORD-Eintrag
ord-ac5c45007cc34363bb2f5ac98ddc5dfa
Quelldatensatz
uspto-grants-2006_04
Patentnummer
US07030120B2

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