3-[9-(2,2,2-Trifluoroethylcarbamoyl)-9H-fluoren-9-yl]propyl bromide → ethyl 2-methyly-3-[4-[3-[9-(2,2,2-trifluoroethylcarbamoyl)-9H-fluoren-9-yl]propyl]piperazin-1-yl]-benzoate
Reaktionsgleichung
[CH3:1][C:2]1[C:12]([N:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)=[CH:11][CH:10]=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5].[F:19][C:20]([F:43])([F:42])[CH2:21][NH:22][C:23]([C:25]1([CH2:38][CH2:39][CH2:40]Br)[C:37]2[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=2[C:31]2[C:26]1=[CH:27][CH:28]=[CH:29][CH:30]=2)=[O:24]>>[CH2:1]=[C:2]1[C:12]([N:13]2[CH2:14][CH2:15][N:16]([CH2:40][CH2:39][CH2:38][C:25]3([C:23](=[O:24])[NH:22][CH2:21][C:20]([F:19])([F:42])[F:43])[C:37]4[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=4[C:31]4[C:26]3=[CH:27][CH:28]=[CH:29][CH:30]=4)[CH2:17][CH2:18]2)=[CH:11][CH:10]=[CH:9][CH:3]1[C:4]([O:6][CH2:7][CH3:8])=[O:5]Komponenten
3
Versuchsvorschrift
The procedure of step (b) of Example 1 was repeated, except that the compound prepared in step (a) of Example 53 and the compound prepared in step (a) of Example 93 were used as the starting compound. Thus, ethyl 2-methyly-3-[4-[3-[9-(2,2,2-trifluoroethylcarbamoyl)-9H-fluoren-9-yl]propyl]piperazin-1-yl]-benzoate was obtained.
Quellen und Nachweise
- ORD-Eintrag
- ord-f3c2ae38d34c4f9e816973e140e24e7b
- Quelldatensatz
- uspto-grants-2006_04
- Patentnummer
- US07030120B2
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