Pyrrolidine → 2-{2-[(2-Chloro-6-fluoro-phenyl)-pyrrolidin-1-yl-methyl]-pyrrol-1-ylmethyl}-pyridine
Reaktionsgleichung
[N:1]1([C:6]2C=CN=[C:8]([CH3:12])[CH:7]=2)[CH:5]=[CH:4][CH:3]=[CH:2]1.[Cl-].[Cl:14][C:15]1[CH:26]=[CH:25][CH:24]=[C:23]([F:27])[C:16]=1[CH:17]=[N+:18]1[CH2:22][CH2:21][CH2:20][CH2:19]1.ClC1C=CC=C(F)C=1C=O.[NH:38]1CC[CH2:40][CH2:39]1>>[Cl:14][C:15]1[CH:26]=[CH:25][CH:24]=[C:23]([F:27])[C:16]=1[CH:17]([N:18]1[CH2:22][CH2:21][CH2:20][CH2:19]1)[C:5]1[N:1]([CH2:6][C:7]2[CH:8]=[CH:12][CH:40]=[CH:39][N:38]=2)[CH:2]=[CH:3][CH:4]=1Komponenten
5
Versuchsvorschrift
The preparation was carried out in accordance with general synthesis instructions 4 from 4-pyrrol-1-yl-methyl-pyridine and 1-(2-chloro-6-fluoro-benzylidene)-pyrrolidinium chloride, which had been prepared in accordance with example 4 from 2-chloro-6-fluorobenzaldehyde and pyrrolidine.