HCID 9834575, Verbindung → HCID 9833987, Verbindung

HRID 1797393Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1797393
C([O:8][CH2:9][CH2:10][C@H:11]([OH:17])[C:12]([CH3:16])([CH3:15])[C:13]#[N:14])C1C=CC=CC=1>[OH-].[OH-].[Pd+2].O1CCCC1>[OH:8][CH2:9][CH2:10][C@H:11]([OH:17])[C:12]([CH3:16])([CH3:15])[C:13]#[N:14]

Komponenten

4

Edukt 1

HCID 9834575HCID 9834575, Verbindung2×

Produkt 1

HCID 9833987HCID 9833987, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 9942167Palladium hydroxideKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

16 g of Pearlman's catalyst (Pd(OH)2 on carbon, 20%) is added to 11.13 g (47.70 mmol) of 5-benzyloxy-2,2-dimethyl-3(S)-hydroxy-pentane-nitrile of the title compound of Example 1c, dissolved in 110 ml of tetrahydrofuran. It is now hydrogenated for 7.5 hours at 10 bar and at room temperature. Catalyst is filtered out, and the filtrate is evaporated to the dry state in a vacuum.

Aufarbeitung

  1. filtrationCatalyst is filtered out
  2. customthe filtrate is evaporated to the dry state in a vacuum

Quellen und Nachweise

ORD-Eintrag
ord-d771bd97d0b1442f9a5d4a7d491a8de9
Quelldatensatz
uspto-grants-2006_04
Patentnummer
US07034165B2

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