Hydrochloric Acid → 2,4-Dihydroxy-6-methoxymethyl-benzaldehyde

HRID 1798059Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1798059
COC[O:4][C:5]1[CH:12]=[C:11]([O:13]COC)[CH:10]=[C:9]([CH2:17][O:18][CH3:19])[C:6]=1[CH:7]=[O:8].Cl>C1COCC1.CCOC(C)=O>[OH:4][C:5]1[CH:12]=[C:11]([OH:13])[CH:10]=[C:9]([CH2:17][O:18][CH3:19])[C:6]=1[CH:7]=[O:8]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 582925712,4-Bis-methoxymethoxy-6-methoxymethyl-benzaldehyde

Produkt 1

HCID 582926702,4-Dihydroxy-6-methoxymethyl-benzaldehydeAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8028TetrahydrofuranLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of 2,4-bis-methoxymethoxy-6-methoxymethyl-benzaldehyde (3.93 g, 14.45 mmol) in THF (30 mL) was added 6 N HCl (10 mL). The mixture was stirred at room temperature for 20 hours then diluted with EtOAc (200 mL). The mixture was washed with brine, dried and concentrated to give 2,4-dihydroxy-6-methoxymethyl-benzaldehyde (2.62 g, 100%). 1H NMR (400 MHz, CDCl3δ 12.40 (s, 1H), 10.10 (s, 1H), 6.41 (s, 1H), 6.30 (s, 1H), 5.60 (s, 1H), 4.61 (s, 2H), 3.40 (s, 3H).

Aufarbeitung

  1. washThe mixture was washed with brine
  2. customdried
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-38a82620bfd6499eaee3241cfee20708
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08343944B2

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