Potassium Carbonate → 1-[(6-Chloropyridin-3-yl)methyl]-4-(propan-2-yl)piperazine

HRID 1798948Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1798948
[CH:1]([N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1)([CH3:3])[CH3:2].[Cl:10][C:11]1[CH:16]=[CH:15][C:14]([CH2:17]Cl)=[CH:13][N:12]=1.C([O-])([O-])=O.[K+].[K+]>CCO>[Cl:10][C:11]1[N:12]=[CH:13][C:14]([CH2:17][N:7]2[CH2:8][CH2:9][N:4]([CH:1]([CH3:3])[CH3:2])[CH2:5][CH2:6]2)=[CH:15][CH:16]=1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 780131-IsopropylpiperazineHCID 1554792-Chloro-5-(chloromethyl)pyridine

Produkt 1

HCID 434217841-[(6-Chloropyridin-3-yl)methyl]-4-(propan-2-yl)piperazine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
65 °C

Versuchsvorschrift

Isopropylpiperazine (2.3 g, 17.94 mmol), 2-chloro-5-chloromethylpyridine (3.2 g, 19.73 mmol) and K2CO3 (26.91 g, 3.713 mmol) were mixed in EtOH (50 mL) a strongly exothermic reaction. The reaction was heated further for 12 hours at 65° C. The reaction mixture was filtered and evaporated. The crude product was used without any further purification.

Aufarbeitung

  1. customa strongly exothermic reaction
  2. filtrationThe reaction mixture was filtered
  3. customevaporated
  4. customThe crude product was used without any further purification

Quellen und Nachweise

ORD-Eintrag
ord-0f22ffb33d324a43b8d7b507ff606544
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08344001B2

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