1-[(6-Chloropyridin-3-yl)methyl]-4-(propan-2-yl)piperazine → 4-[5-(4-Isopropylpiperazin-1-ylmethyl)pyridin-2-yl]-N,N-dimethylbenzenesulfonamide, trihydrochloride

HRID 1798952Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1798952
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][N:9]2[CH2:14][CH2:13][N:12]([CH:15]([CH3:17])[CH3:16])[CH2:11][CH2:10]2)=[CH:4][CH:3]=1.[CH3:18][N:19]([CH3:32])[S:20]([C:23]1[CH:28]=[CH:27][C:26](B(O)O)=[CH:25][CH:24]=1)(=[O:22])=[O:21]>>[ClH:1].[ClH:1].[ClH:1].[CH:15]([N:12]1[CH2:13][CH2:14][N:9]([CH2:8][C:5]2[CH:4]=[CH:3][C:2]([C:26]3[CH:25]=[CH:24][C:23]([S:20]([N:19]([CH3:32])[CH3:18])(=[O:21])=[O:22])=[CH:28][CH:27]=3)=[N:7][CH:6]=2)[CH2:10][CH2:11]1)([CH3:17])[CH3:16]

Komponenten

3

Edukt 2

HCID 434217841-[(6-Chloropyridin-3-yl)methyl]-4-(propan-2-yl)piperazineHCID 441193284-(N,N-Dimethylsulphonamido)benzeneboronic acid

Produkt 1

HCID 1317301384-[5-(4-Isopropylpiperazin-1-ylmethyl)pyridin-2-yl]-N,N-dimethylbenzenesulfonamide, trihydrochloride

Versuchsvorschrift

1-(6-Chloropyridin-3-ylmethyl)-4-isopropylpiperazine (0.5 g, 1.97 mmol) and 4-(N,N-dimethylaminosulfonyl)phenylboronic acid (0.496 g, 2.2 mmol)) were mixed with catalyst and reacted in the same manner as in example 18. The title compound was isolated as white crystals of the trihydrochloride. Yield: 660 g (71%)

Aufarbeitung

  1. customreacted in the same manner as in example 18

Quellen und Nachweise

ORD-Eintrag
ord-3cb89b0f36104ff1830c969c608a4ac6
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08344001B2

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