Chlorosulfonic acid → HCID 58433497, Verbindung

HRID 1798957Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1798957
[Cl:1][C:2]1[C:3]([NH:12][CH2:13][C:14]2([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[Cl:26][S:27](O)(=[O:29])=[O:28]>C(Cl)Cl>[Cl:1][C:2]1[C:3]([NH:12][CH2:13][C:14]2([C:20]3[CH:25]=[CH:24][C:23]([S:27]([Cl:26])(=[O:29])=[O:28])=[CH:22][CH:21]=3)[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:9])[F:10])[CH:7]=1

Komponenten

4

Edukt 2

HCID 24638Chlorosulfonic acidHCID 58433490HCID 58433490, Verbindung

Produkt 1

HCID 58433497HCID 58433497, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

185 mg of (3-Chloro-5-trifluoromethyl-pyridin-2-yl)-(1-phenyl-cyclohexylmethyl)-amine were dissolved in 15 ml of methylenchloride and 0.14 ml of chlorosulfonic acid were added. The reaction mixture was stirred at room temperature for 4 days and than poured on ice water (20 ml). The organic layer was separated, washed twice with 50 ml of brine and then dried over MgSO4. The solvent was removed in vacuo to obtain 194 mg g of the crude product.

Aufarbeitung

  1. additionthan poured on ice water (20 ml)
  2. customThe organic layer was separated
  3. washwashed twice with 50 ml of brine
  4. dry with materialdried over MgSO4
  5. customThe solvent was removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-d9707b838f96458a80063c53f79f016e
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08344004B2

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