4-(3,3,3-Trifluoropropoxy)benzoic acid → 2-[((2S)-3-[4-(Trifluoromethoxy)phenyl]-2-{[4-(3,3,3-trifluoropropoxy)benzoyl]amino}propanoyl)amino]ethyl acetate

HRID 1799271

Reaktionsgleichung

Reaktionsgleichung von HRID 1799271
[C:1]([O:4][CH2:5][CH2:6][NH:7][C:8](=[O:23])[C@@H:9]([NH2:22])[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][C:18]([F:21])([F:20])[F:19])=[CH:13][CH:12]=1)(=[O:3])[CH3:2].[F:24][C:25]([F:39])([F:38])[CH2:26][CH2:27][O:28][C:29]1[CH:37]=[CH:36][C:32]([C:33](O)=[O:34])=[CH:31][CH:30]=1>>[C:1]([O:4][CH2:5][CH2:6][NH:7][C:8](=[O:23])[C@@H:9]([NH:22][C:33](=[O:34])[C:32]1[CH:36]=[CH:37][C:29]([O:28][CH2:27][CH2:26][C:25]([F:39])([F:38])[F:24])=[CH:30][CH:31]=1)[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][C:18]([F:21])([F:19])[F:20])=[CH:13][CH:12]=1)(=[O:3])[CH3:2]

Komponenten

3

Edukt 2

HCID 581116554-(3,3,3-Trifluoropropoxy)benzoic acidHCID 690175432-({(2S)-2-amino-3-[4-(trifluoromethoxy)phenyl]propanoyl}amino)ethyl acetate

Produkt 1

HCID 866365282-[((2S)-3-[4-(Trifluoromethoxy)phenyl]-2-{[4-(3,3,3-trifluoropropoxy)benzoyl]amino}propanoyl)amino]ethyl acetate

Versuchsvorschrift

A reaction similar to that described in Example 50 was conducted using 2-({(2S)-2-amino-3-[4-(trifluoromethoxy)phenyl]propanoyl}amino)ethyl acetate and 4-(3,3,3-trifluoropropoxy)benzoic acid obtained in the preparation process of Example 33 (33a) to give the title compound.

Aufarbeitung

  1. customA reaction similar to

Quellen und Nachweise

ORD-Eintrag
ord-51dd829be42c434d97bbd61c8335b8b7
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08344029B2

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