HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2,2-Difluoroethanamine → N-{2-[(2,2-Difluoroethyl)amino]-2-oxo-1-[4-(trifluoromethoxy)benzyl]ethyl}-4-(3,3,3-trifluoropropoxy)benzamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2,2-Difluoroethanamine | HCID 136274 | — |
| Edukt | 3-[4-(Trifluoromethoxy)phenyl]-2-{[4-(3,3,3-trifluoropropoxy)benzoyl]amino}propanoic acid | HCID 78068623 | — |
| Produkt | N-{2-[(2,2-Difluoroethyl)amino]-2-oxo-1-[4-(trifluoromethoxy)benzyl]ethyl}-4-(3,3,3-trifluoropropoxy)benzamide | HCID 57972095 | 80,9% |
Reaktionsschritte
A reaction similar to that described in Example 32 (32c) was conducted using 3-[4-(trifluoromethoxy)phenyl]-2-{[4-(3,3,3-trifluoropropoxy)benzoyl]amino}propanoic acid (233 mg) prepared in Example 70 (70a) and 2,2-difluoroethylamine (49 mg) to give 214 mg of the title compound (white powder).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08344029B2 |
| Quelldatensatz | uspto-grants-2013_01 |
| ORD ID | ord-fd50158923be47fdb6e1e13c46603f1e |
| Quellennotiz | uspto-grants-2013_01 |