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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 1799290Erstellt: 25. Oktober 2026

2-Amino-3-[4-(trifluoromethoxy)phenyl]propanoic acid hydrochloride → 2-{[2-Fluoro-4-(3,3,3-trifluoropropoxy)benzoyl]amino}-3-[4-(trifluoromethoxy)phenyl]propanoic acid

https://huagongshe.com/reaction/1799290

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
Edukt2-Amino-3-[4-(trifluoromethoxy)phenyl]propanoic acid hydrochlorideHCID 22603340—
Edukt2-Fluoro-4-(3,3,3-trifluoropropoxy)benzoic acidHCID 69019004—
Produkt2-{[2-Fluoro-4-(3,3,3-trifluoropropoxy)benzoyl]amino}-3-[4-(trifluoromethoxy)phenyl]propanoic acidHCID 8765767593,7%

Reaktionsschritte

A reaction similar to that described in Example 70 (70a) was conducted using 2-fluoro-4-(3,3,3-trifluoropropoxy)benzoic acid (177 mg) prepared in Example 84 (84a) and 2-amino-3-[4-(trifluoromethoxy)phenyl]propanoic acid hydrochloride (200 mg) prepared in Reference Example 2 to give 317 mg of the title compound (white powder).

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS08344029B2
Quelldatensatzuspto-grants-2013_01
ORD IDord-16f7d383c3bd46be9e793895133f6427
Quellennotizuspto-grants-2013_01