Hydrochloric Acid → 2-Amino-3-[4-(trifluoromethoxy)phenyl]propanoic acid hydrochloride

HRID 1799295Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1799295
[ClH:1].C1(C(=[N:15][CH:16]([CH2:24][C:25]2[CH:30]=[CH:29][C:28]([O:31][C:32]([F:35])([F:34])[F:33])=[CH:27][CH:26]=2)[C:17]([O:19]C(C)(C)C)=[O:18])C2C=CC=CC=2)C=CC=CC=1>>[ClH:1].[NH2:15][CH:16]([CH2:24][C:25]1[CH:26]=[CH:27][C:28]([O:31][C:32]([F:33])([F:34])[F:35])=[CH:29][CH:30]=1)[C:17]([OH:19])=[O:18]

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 86636533Tert-butyl 2-[(diphenylmethylene)amino]-3-[4-(trifluoromethoxy)phenyl]propanoate

Produkt 1

HCID 226033402-Amino-3-[4-(trifluoromethoxy)phenyl]propanoic acid hydrochlorideAusbeute 91 %

Versuchsvorschrift

A 6 N hydrochloric acid (1 mL) solution of tert-butyl 2-[(diphenylmethylene)amino]-3-[4-(trifluoromethoxy)phenyl]propanoate (64 mg, 0.136 mmol) prepared in Reference Example 1 (1a) was heated under reflux for 6 hours and then cooled to room temperature. The reaction solution was concentrated under reduced pressure, and the residue was washed with diethyl ether to give 35 mg of the title compound (white powder, yield: 91%).

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for 6 hours
  3. concentrationThe reaction solution was concentrated under reduced pressure
  4. washthe residue was washed with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-62b17dd45f2a4349963c10e8c832a9d8
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08344029B2

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