Hydrochloric Acid → (S)-2-Amino-3-(4-(trifluoromethoxy)phenyl)propanoic acid hydrochloride
Reaktionsgleichung
C([NH:4][C@@H:5]([CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][C:18]([F:21])([F:20])[F:19])=[CH:13][CH:12]=1)[C:6]([O:8]C)=[O:7])(=O)C.[ClH:22]>>[ClH:22].[NH2:4][C@@H:5]([CH2:10][C:11]1[CH:12]=[CH:13][C:14]([O:17][C:18]([F:19])([F:20])[F:21])=[CH:15][CH:16]=1)[C:6]([OH:8])=[O:7]Komponenten
3
Reaktionsbedingungen
- Temperatur
- 100 °C
Versuchsvorschrift
A 6 N hydrochloric acid (330 μL) solution of methyl (2S)-2-(acetylamino)-3-[4-(trifluoromethoxy)phenyl]propanoate (29.9 mg, 0.098 mmol) prepared in Reference Example 3 (3f) was stirred at 100° C. for 4 hours. The reaction solution was cooled to room temperature and then concentrated under reduced pressure. The obtained residue was azeotroped with toluene, washed with diethyl ether, and dried under reduced pressure to give 26 mg of the title compound (white powder, yield: 93%).