m-Chloroperbenzoic acid → Methyl 2-methylnicotinate 1-oxide

HRID 1799542

Reaktionsgleichung

Reaktionsgleichung von HRID 1799542
[CH3:1][C:2]1[C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.C1C=C(Cl)C=C(C(OO)=[O:20])C=1>C(Cl)Cl>[CH3:1][C:2]1[C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=[CH:4][N+:3]=1[O-:20]

Komponenten

4

Edukt 2

HCID 70297m-Chloroperbenzoic acidHCID 7015327Methyl 2-methylnicotinate

Produkt 1

HCID 20163965Methyl 2-methylnicotinate 1-oxide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Methyl 2-methylpyridine-3-carboxylate (10 g, 66.2 mmol) was taken up in DCM (140 mL) and mCPBA (16.31 g, 72.8 mmol) was added. The resulting solution was stirred at room temperature overnight. The reaction mixture was purified directly by silica gel chromatography (0-20% MeOH/EtOAc) to afford the title compound as a beige solid.

Aufarbeitung

  1. customThe reaction mixture was purified directly by silica gel chromatography (0-20% MeOH/EtOAc)

Quellen und Nachweise

ORD-Eintrag
ord-5826699f908e498497767f14fa30e8d5
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08344144B2

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