Tert-butyl {4-methyl-3-[(6-nitropyridin-3-yl)oxy]phenyl}carbamate → Tert-butyl {3-[(6-aminopyridin-3-yl)oxy]-4-methylphenyl}carbamate

HRID 1800411Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1800411
[C:1]([O:5][C:6](=[O:25])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([CH3:14])=[C:10]([O:15][C:16]2[CH:17]=[N:18][C:19]([N+:22]([O-])=O)=[CH:20][CH:21]=2)[CH:9]=1)([CH3:4])([CH3:3])[CH3:2]>CO.[C].[Pd]>[C:1]([O:5][C:6](=[O:25])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([CH3:14])=[C:10]([O:15][C:16]2[CH:17]=[N:18][C:19]([NH2:22])=[CH:20][CH:21]=2)[CH:9]=1)([CH3:4])([CH3:2])[CH3:3]

Komponenten

4

Edukt 1

HCID 57749145Tert-butyl {4-methyl-3-[(6-nitropyridin-3-yl)oxy]phenyl}carbamate

Produkt 1

HCID 57749176Tert-butyl {3-[(6-aminopyridin-3-yl)oxy]-4-methylphenyl}carbamateAusbeute 100,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of tert-butyl{4-methyl-3-[(6-nitropyridin-3-yl)oxy]phenyl}carbamate (1.85 g, 5.35 mmol) in methanol (10 mL) was added palladium carbon (50% water-containing product, 100 mg), and the mixture was stirred at room temperature for 3 hr under a hydrogen atmosphere of 1.0 pressure. The reaction mixture was filtered through celite, the filtrate was concentrated under reduced pressure, and the residue was dried to give the title compound (1.69 g, 99%) as a colorless oil.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customthe residue was dried

Quellen und Nachweise

ORD-Eintrag
ord-a6990a0eed0643df8140e6bcedc7d558
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08344135B2

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