5-Nitro-2-(trifluoromethyl)phenol → 5-Amino-2-trifluoromethyl-phenol

HRID 1800496Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1800496
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([C:11]([F:14])([F:13])[F:12])=[C:8]([OH:10])[CH:9]=1)([O-])=O>CO.[C].[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([C:11]([F:12])([F:13])[F:14])=[C:8]([OH:10])[CH:9]=1

Komponenten

4

Edukt 1

HCID 219595865-Nitro-2-(trifluoromethyl)phenol

Produkt 1

HCID 159190985-Amino-2-trifluoromethyl-phenolAusbeute 84 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 5-nitro-2-(trifluoromethyl)phenol (2.22 g, 10.7 mmol) in methanol (30 mL) was added 10% palladium-carbon (440 mg), and the mixture was stirred at room temperature for 8 hr under a hydrogen atmosphere (1 atm). The insoluble material was filtered off, and the filtrate was concentrated under reduced pressure. The obtained residue was crystallized from ethyl acetate/hexane to give the title compound (1.59 g, 84%) as a pale-brown solid.

Aufarbeitung

  1. filtrationThe insoluble material was filtered off
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customThe obtained residue was crystallized from ethyl acetate/hexane

Quellen und Nachweise

ORD-Eintrag
ord-bedbefe3486e462d9fb13db30ae2e8bd
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08344135B2

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