Hydrogen chloride-ethyl acetate → 6-Azaspiro[2.5]octane--hydrogen chloride (1/1)

HRID 1800604

Reaktionsgleichung

Reaktionsgleichung von HRID 1800604
[CH2:1]1[C:3]2([CH2:8][CH2:7][N:6](C(OC(C)(C)C)=O)[CH2:5][CH2:4]2)[CH2:2]1.[ClH:16].C(OCC)(=O)C>O1CCCC1>[ClH:16].[CH2:2]1[C:3]2([CH2:8][CH2:7][NH:6][CH2:5][CH2:4]2)[CH2:1]1

Komponenten

4

Edukt 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 51358341Tert-butyl 6-azaspiro[2.5]octane-6-carboxylate

Produkt 1

HCID 545931876-Azaspiro[2.5]octane--hydrogen chloride (1/1)Ausbeute 85,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

Tert-butyl 6-azaspiro[2.5]octane-6-carboxylate (261 mg, 1.23 mmol) was dissolved in tetrahydrofuran (5 mL), 4N hydrochloric acid/ethyl acetate solution (2 mL, 8.00 mmol) was added, and the mixture was stirred at 50° C. for 24 hr. The reaction mixture was concentrated under reduced pressure to give the title compound (155 mg, 85%) as white crystals.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e4b3a222fdea47e4ac21dbf20233476a
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08344135B2

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