7-Methoxy-1,2-dihydroquinoxalin-2-one → (RS)-2-tert-butoxycarbonylamino-3-(7-methoxy-2-oxo-2H-quinoxalin-1-yl)-propionic acid methyl ester

HRID 1801457

Reaktionsgleichung

Reaktionsgleichung von HRID 1801457
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([N:7]=[CH:8][C:9](=[O:13])[NH:10]2)=[CH:5][CH:4]=1.[CH3:14][O:15][C:16](=[O:27])[C:17](=[CH2:26])[NH:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20]>>[CH3:14][O:15][C:16](=[O:27])[CH:17]([NH:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:26][N:10]1[C:11]2[C:6](=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[CH:12]=2)[N:7]=[CH:8][C:9]1=[O:13]

Komponenten

3

Edukt 2

HCID 4913197-Methoxy-1,2-dihydroquinoxalin-2-oneHCID 10932500Methyl 2-((tert-butoxycarbonyl)amino)prop-2-enoate

Produkt 1

HCID 68783315(RS)-2-tert-butoxycarbonylamino-3-(7-methoxy-2-oxo-2H-quinoxalin-1-yl)-propionic acid methyl esterAusbeute 20 %

Versuchsvorschrift

The compound (yellow solid; 370 mg, 20% yield) was obtained according to procedure H starting from 7-methoxyquinoxalin-2(1H)-one (prepared according to WO 2006/134378) and N-(tert-butoxycarbonyl)dehydroalanine methyl ester.

Aufarbeitung

  1. customThe compound (yellow solid; 370 mg, 20% yield) was obtained

Quellen und Nachweise

ORD-Eintrag
ord-4a5a44a172714127be1b63492c7585ad
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08349826B2

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